C-TERMINAL PEPTIDE MODIFICATIONS REVEAL DIRECT AND INDIRECT ROLES OF HEDGEHOG MORPHOGEN CHOLESTEROYLATION

Hedgehog (Hh) morphogens are involved in embryonic development and stem cell biology and, if misregulated, can contribute to cancer.One important Duffel Bag post-translational modification with profound impact on Hh biofunction is its C-terminal cholesteroylation during biosynthesis.The current hypothesis is that the cholesterol moiety is a decisiv

Liyao Liu, Cuiping Zhou, Xuejun Xia, Yuling Liu State Key Laboratory of Bioactive Substance and Function of Natural Corks Medicines, Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, Peo